PRODUCTION OF HUPERZINE A BY FUNGAL ENDOPHYTES ASSOCIATED WITH HUPERZIACEAE PLANTS

Background: Endophytic fungi are known as a producer of myriad bioactive natural products, including those originally produced by the host plants. Huperzine A (Hup A), lycopodium alkaloid, which was reported an active acetylcholinesterase inhibitor (AChEI) agent used for treatment Alzheimer’s disease, isolated from medicinal Chinese herbs Huperzia serrata. Moreover, various species endophytic associated with H. serrata and other within Huperziaceae plants were found capable producing Hup A, suggesting these microorganisms promising sources A. Objective: This review aimed to summarize evidence part efforts assess alternative Methods: Scientific articles on published 2000 until 2022 screened through scientific databases. Results: Thirty-two fungal strains belonging fifteen genera documented These endophytes plants, serrata, Phlegmariurus phlegmaria taxifolius. Conclusion: We herein capability produce AChEI agent, could be considered larger scale.Keywords: Acetylcholinesterase (AChEI); disease; Fungal endophytes; Huperziaceae; A).